LoTox™ recomb.Phl p 5a (LTR-PP5A-1)

Allergen: rPhl p 5a (Phleum pratense allergen 5a), Timothy

Unit: 250ug

Source: E. coli

Mol. Wt: ~28 kD

Purification: Multi-step chromatographic purification. Purity > 95 % by SDS-PAGE

Concentration: See product insert.

Formulation: In sterile, endotoxin free 1x PBS, pH 7.4

Storage: Store at -20ºC; Avoid repeated Freeze/Thaw cycles.

Notes: (1) A LoTox™ product: Endotoxin <0.03 EU/µg.
(2) LoToxTM rPhl p 5a has a C-terminal 7xHis-tag

Genbank: AJ555152

PDB: 1L3P

Product Resources: LoTox™ Recombinant Phl p 5a Certificate of Analysis

Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.

References:

1. Niederberger V, Laffer S, Froschl R, Kraft D, et al. IgE antibodies to recombinant pollen allergens (Phl p 1, Phl p 2, Phl p 5, and Bet v 2) account for a high percentage of grass pollen-specific IgE. J Allergy Clin Immunol 1998;101:258-64.
2. Mari A. Skin test with a timothy grass (Phleum pratense) pollen extract vs. IgE to a timothy extract vs. IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data. Clin Exp Allergy 2003;33:43-51.
3. Jutel M, Jaeger L, Suck R, et al. Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 2005;116:608-13.