Natural Cor a 9 (NA-CA9-1)

Allergen:	nCor a 9 (Corylus avellana allergen 9), hazelnut
Unit:	250µg
Source:	11S globulin from hazelnut.
Mol. Wt:	Multiple subunits ranging from 30 to 59 kD
Purification:	Purified from hazelnut extract by multi-step HPLC. Purity > 95 % by silver stained SDS-PAGE.
Concentration:	See product insert.
Formulation:	Preservative and carrier-free in 1M NaCl, PBS pH 7.40. Filtered through 0.22µm filter.
Storage:	Store at -20ºC. Avoid repeated freeze-thaw cycles
Notes:	(1) 11S globulins are synthesized as single peptide chain precursors that are cleaved post-translationally. (2) Solubility of Cor a 9 is dependent on the presence of at least 1M NaCl.
Genbank:
PDB:
Product Resources:	Natural Cor a 9 Certificate of Analysis
Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
1. Beyer K et al. Identification of an11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions. J Allergy Clin Immunol. 2002;110(3):517-23. 2. Guo Fet al. Purification and crystallization of Cor a 9, a major hazelnut allergen. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:42-6. 3. Masthoff LJ et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J Allergy Clin Immunol. 2013;132(2):393-9