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Grants

Indoor Biotechnologies has received over $3 million in external research funding since 2006 and has active collaborations with research groups in academia and industry.Grants from the National Institutes of Health, the European Union, government agencies and research foundations, support our research on:

A. Determinants of allergenicity

Dr. Pomés was awarded R01 grant AI077653 by the National Institute of Allergy and Infectious Diseases (NIAID) in 2009, and an Administrative Supplement from American Recovery and Reinvestment Act (ARRA) Funds in 2010. The aims are to determine the structures of major mite and cockroach allergens and allergen antibody complexes by X-ray crystallography. The structure of antibody binding epitopes is defined and site-directed mutagenesis is used to identify IgE antibody binding sites. Mutants are analyzed for T cell responses in mite or cockroach allergic patients. This research aims to develop hypoallergenic variants of allergens that may be used in new forms of allergen immunotherapy.

The main goal of the ARRA Award was to develop molecular diagnostics to measure IgE antibody binding to specific cockroach allergens, as part of a resource for collaborating with the Inner City Asthma Consortium. The project involved the production of monoclonal antibodies against cockroach allergens that will be used for the development of assays to measure IgE antibodies against cockroach allergens. A Research Associate position was also created as a result of this Award.

B. Development of new environmental detection technologies

  • The Ventia™ rapid test for dust mite. Funded in part by a Small Business Innovation Research (SBIR) award from the National Institute for Environmental Health Sciences (NIEHS) (ES011920).
  • Fluorescent multiplex array technology for indoor allergens (MARIA®). Funded in part by a SBIR award from the NIEHS (ES55545C)
  • Multiplex array for measuring markers of mold exposure. Funded in part by a SBIR award from the NIEHS (SBIR HHSN273201000008C).
  • High throughput immunoassay to monitor flagellin exposure in the environment. Funded in part by a SBIR award from the NIEHS (1R43ES022879).
  • Development of purified allergen standards and to compare sensitivity, specificity and reproducibility of ELISA measurements for allergens, as part of the 5th Framework Programme of the European Union CREATE project (Contract G6RD-CT-2001-00582).

Financial Conflict of Interest Policy

Indoor Biotechnologies has developed a Financial Conflict of Interest Policy (FCOI) in accordance with Federal and NIH requirements for Public Health Service funded research (42 CFR Part 50 Subpart F).  This policy promotes objectivity in research and includes requirements for training of investigators, monitoring FCOI, reporting to NIH and ensuring compliance.  Contact Dr. Anna Pomés if you have questions about this policy.