Natural Bet v 1 (NA-BV1-1)

Description
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Allergen:	nBet v 1 (Betula pendula allergen 1), European white birch
Unit:	250 µg
Source:	Birch pollen (Betula pendula)
Mol. Wt:	18 kDa
Purification:	From birch pollen extract by multi-step chromatography. Purity > 95 % by silver stained SDS-PAGE
Concentration:	See product insert.
Formulation:	Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.
Storage:	Store at -20ºC. Avoid repeated freeze-thaw cycles.
Notes:	Purified natural Bet v 1 appears as a triplet of 18-20kD proteins representing distinct isoforms of Bet v 1 (1).
PDB:
Product Resources:	Natural Bet v 1 Certificate of Analysis
Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
Batard, T. et al: Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy. Int Arch Allergy Immunol 2005, 136 (3), 239-249. Breiteneder, H.et al: The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J 1989, 8 (7), 1935-1938. Spangfort, M. D.et al:Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. J Immunol 2003, 171 (6), 3084-3090. Swoboda, I.et al: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995, 270 (6), 2607-2613 Vieths, S et al.: Establishment of recombinantmajor allergens Bet v 1 and Phl p 5a as Ph. Eur. Reference standardsand validation of ELISA methods for their measurement. Pharmeuropa Bio & SN 2012; 118-13.